Scientists design a chip with nanotechnology to deliver biological cargo to injuries allowing cell regeneration and resotrative function

 

Orange County, CA - August 9th 2017 - Scientists at The Ohio State University Wexner Medical Center and The Ohio State College of Engineering have developed a chip incorporating nanotechnology to deliver biological “cargo.” In doing so, the injured tissue will be able to regenerate  and restore any functions of aging tissue, blood vessels, organs and nerve cells. Results of the study can be found in the journal Nature Nanotechnology.

This new technology, Tissue Nanotransfection (TNT), can produce any cell type within a patient’s body necessary for treatment. TNT technology has the potential to help deployed soldiers injured on site, for its dime-sized silicone chip "injects genetic code into skin cells, turning those skin cells into other types of cells required for treating diseased conditions," according to a release. “This technology does not require a laboratory or hospital and can actually be executed in the field," said Dr. Chanden Sen, director of Ohio State’s Center for Regenerative Medicine & Cell Based Therapies and leader of the study. "It’s less than 100 grams to carry and will have a long shelf life. By using our novel nanochip technology, injured or compromised organs can be replaced. We have shown that skin is a fertile land where we can grow the elements of any organ that is declining,” said Dr. Sen.

During trials on mice and pigs, researchers were able to reprogram skin cells to become vascular cells on badly damaged legs lacking blood flow. Within a week active blood cells had returned to the site of injury, and by the second week the leg was saved. Scientists were also able to reprogram skin cells into nerve cells to be injected into mice to aid in recovery from strokes.

Scientists design a chip with nanotechnology to deliver biological cargo to injuries allowing cell regeneration and resotrative function

This is difficult to imagine, but it is achievable, successfully working about 98 percent of the time. With this technology, we can convert skin cells into elements of any organ with just one touch. This process only takes less than a second and is non-invasive, and then you're off. The chip does not stay with you, and the reprogramming of the cell starts. Our technology keeps the cells in the body under immune surveillance, so immune suppression is not necessary,” said Sen, who also is executive director of Ohio State’s Comprehensive Wound Center.

TNT technology is comprised of two main components: the chip that delivers the cargo to the damaged cells, and the biological makeup of the cargo delivered.  By delivering the biological cargo, cells are converted from one cell type to another, dependent on predetermined programming for replication. The biological cargo is delivered by zapping the chip with a small electrical charge barely perceived by patients. “The concept is very simple,” said L. James Lee, professor of chemical and biomolecular engineering with Ohio State’s College of Engineering in collaboration with Ohio State’s Nanoscale Science and Engineering Center. “As a matter of fact, we were even surprised how it worked so well. In my lab, we have ongoing research trying to understand the mechanism and do even better. So, this is the beginning, [of] more to come.”

The chip is awaiting FDA approval, but Sen is optimistic and expects TNT will be tested on humans within the year.

 

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Scientists design a chip with nanotechnology to deliver biological cargo to injuries allowing cell regeneration and resotrative function   Orange County, CA – August 9th 2017 – Scientists at The Ohio State University Wexner Medical Center and The Ohio State College of Engineering have developed a chip incorporating nanotechnology to deliver biological “cargo.” In doing so, […]